Anti-CD38 monoclonal antibodies continue to demonstrate promising results as new treatments for patients with multiple myeloma. Therapeutic anti-CD38 targets this molecule, highly expressed on the surface of multiple myeloma cells, hampering its detection by flow cytometry.
Cytognos has developed an anti-human CD38 multi-epitope reagent containing a mixture of antibodies that allows the identification by flow cytometry of CD38 molecule on plasma cells, even in patients under anti-CD38 therapy.
Comparative evaluation by flow cytometry of CD38-FITC monoclonal (dark grey dots) and CD38-FITC multi-epitope (CYT-38F2; red dots) performance. A) Bone marrow sample from untreated patient. B) Patient treated with therapy 1. C) Patient treated with therapy 2.